sixty-six source-reviewed stories explain what human studies, early
trials, biomarkers and laboratory research can—and cannot—tell us
about healthier aging.
ASPREE’s broader healthspan composite stayed near the null
A later analysis combined five very different first events. Aspirin and placebo rates were nearly identical—but the way the endpoint was built matters as much as the result.
The newest findings—and what they mean for healthy aging.
Each story names the studied population, outcome, limits, safety
context and sources—without turning a promising signal into a
longevity promise.
Evidence Explainer
Health & function
Why primary, secondary and subgroup trial results carry different weight
A result makes sense only beside the question fixed before the data, the people actually analyzed and the uncertainty around the estimate.
Methods guidance with bounded examples from two human randomized trialsRead the explainer →
Research Analysis
Drugs & supplements
A 24-week NMN trial raised blood NAD—not hearing or physical function
In selected healthy Japanese adults age 65 or older, high-dose NMN produced a large biochemical change. The registered hearing outcome and measured physical function did not improve.
Human biomarkers and function · small 24-week randomized trialRead the analysis →
Evidence Explainer
Health & function
Why “frailty” can mean different things in different studies
Physical features, accumulated deficits and performance tasks measure different inputs. Learn what a changed frailty score can and cannot establish.
Human measurement methods · historical observational validation, with consensus and molecular contextRead the explainer →
Research Analysis
Everyday foundations
A four-week pectin pilot found signals—not proof of frailty benefit
In 31 older adults with frailty or pre-frailty, low-methoxy pectin did not change the inflammatory outcomes the paper defined as primary. Secondary and exploratory signals remain preliminary.
Human frailty/pre-frailty · small randomized four-week nutrition pilotRead the story →
Research Analysis
Everyday foundations
Cutting protein did not raise blood-cell autophagy in one trial
A four-week crossover trial found no detectable average increase in fasting immune-cell autophagic flux. It did not test other tissues, older adults, healthspan or lifespan.
Human blood-cell autophagic flux · small randomized crossover nutrition trialRead the story →
Research Analysis
Health & function
A review found healthspan signals—and no common effect
Fifteen randomized studies measured intrinsic capacity, quality of life or other multidimensional scores. Their results could be described study by study—not combined into extra healthy years or a treatment ranking.
Choose an introduction or intervention path—or begin with heart health, cognition, or staying strong and independent. Every step explains why it follows.
Learn
Spot the difference between a promising signal and a proven benefit.
Short guides explain evidence maturity, clinical trials and
biomarkers. Editorial standards and the development record remain
available in the trust links below.